| Publication Type: | Journal Article |
| Year of Publication: | 2010 |
| Authors: | Y. Song, Zhao, Q. - J., Jin, Y. - S., Feng, C. - W., Chen, H. - S. |
| Journal: | Arch Pharm Res |
| Volume: | 33 |
| Issue: | 12 |
| Pagination: | 1933-6 |
| Date Published: | 2010 Dec |
| ISSN: | 0253-6269 |
| Keywords: | Antineoplastic Agents, Phytogenic, Cell Line, Tumor, Cell Proliferation, HCT116 Cells, Hep G2 Cells, HL-60 Cells, Humans, Kadsura, Magnetic Resonance Spectroscopy, Plant Extracts, Plant Roots, Triterpenes |
| Abstract: | An investigation of EtOAc extracts of Kadsura coccinea (Lem.) A. C. Smith, has led to the isolation of two new compounds characterized as 3-hydroxy-12-hydroxyl coccinic acid (1) and 3-hydroxy-neokadsuranic acid A (2). Their structures were established by 1D and 2D NMR techniques and mass spectroscopy. Antiproliferative effects of the isolated compounds were evaluated against four human tumor cell lines (A549, HCT116, HL-60 and HepG2), and it was found that compound 1 exhibited antiproliferative effects with IC(50) values ranging from 3.01 to 18.08 μg/mL. |
| DOI: | 10.1007/s12272-010-1207-0 |
| Alternate Journal: | Arch. Pharm. Res. |
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