Hodgsonia, Kadsura and Paris in Thailand

Conserved plants of Plant Genetic Conservation Project (RSPG)

Two new triterpenoid acids from Kadsura coccinea.

Publication Type:Journal Article
Year of Publication:2010
Authors:Y. Song, Zhao, Q. - J., Jin, Y. - S., Feng, C. - W., Chen, H. - S.
Journal:Arch Pharm Res
Date Published:2010 Dec
Keywords:Antineoplastic Agents, Phytogenic, Cell Line, Tumor, Cell Proliferation, HCT116 Cells, Hep G2 Cells, HL-60 Cells, Humans, Kadsura, Magnetic Resonance Spectroscopy, Plant Extracts, Plant Roots, Triterpenes

An investigation of EtOAc extracts of Kadsura coccinea (Lem.) A. C. Smith, has led to the isolation of two new compounds characterized as 3-hydroxy-12-hydroxyl coccinic acid (1) and 3-hydroxy-neokadsuranic acid A (2). Their structures were established by 1D and 2D NMR techniques and mass spectroscopy. Antiproliferative effects of the isolated compounds were evaluated against four human tumor cell lines (A549, HCT116, HL-60 and HepG2), and it was found that compound 1 exhibited antiproliferative effects with IC(50) values ranging from 3.01 to 18.08 μg/mL.

Alternate Journal:Arch. Pharm. Res.
Scratchpads developed and conceived by (alphabetical): Ed Baker, Katherine Bouton Alice Heaton Dimitris Koureas, Laurence Livermore, Dave Roberts, Simon Rycroft, Ben Scott, Vince Smith