Hodgsonia, Kadsura and Paris in Thailand

Conserved plants of Plant Genetic Conservation Project (RSPG)

Two new triterpenoid acids from Kadsura coccinea.

Publication Type:Journal Article
Year of Publication:2010
Authors:Y. Song, Zhao, Q. - J., Jin, Y. - S., Feng, C. - W., Chen, H. - S.
Journal:Arch Pharm Res
Volume:33
Issue:12
Pagination:1933-6
Date Published:2010 Dec
ISSN:0253-6269
Keywords:Antineoplastic Agents, Phytogenic, Cell Line, Tumor, Cell Proliferation, HCT116 Cells, Hep G2 Cells, HL-60 Cells, Humans, Kadsura, Magnetic Resonance Spectroscopy, Plant Extracts, Plant Roots, Triterpenes
Abstract:

An investigation of EtOAc extracts of Kadsura coccinea (Lem.) A. C. Smith, has led to the isolation of two new compounds characterized as 3-hydroxy-12-hydroxyl coccinic acid (1) and 3-hydroxy-neokadsuranic acid A (2). Their structures were established by 1D and 2D NMR techniques and mass spectroscopy. Antiproliferative effects of the isolated compounds were evaluated against four human tumor cell lines (A549, HCT116, HL-60 and HepG2), and it was found that compound 1 exhibited antiproliferative effects with IC(50) values ranging from 3.01 to 18.08 μg/mL.

DOI:10.1007/s12272-010-1207-0
Alternate Journal:Arch. Pharm. Res.
Scratchpads developed and conceived by (alphabetical): Ed Baker, Katherine Bouton Alice Heaton Dimitris Koureas, Laurence Livermore, Dave Roberts, Simon Rycroft, Ben Scott, Vince Smith