|Publication Type:||Journal Article|
|Year of Publication:||2010|
|Authors:||Y. Song, Zhao, Q. - J., Jin, Y. - S., Feng, C. - W., Chen, H. - S.|
|Journal:||Arch Pharm Res|
|Date Published:||2010 Dec|
|Keywords:||Antineoplastic Agents, Phytogenic, Cell Line, Tumor, Cell Proliferation, HCT116 Cells, Hep G2 Cells, HL-60 Cells, Humans, Kadsura, Magnetic Resonance Spectroscopy, Plant Extracts, Plant Roots, Triterpenes|
An investigation of EtOAc extracts of Kadsura coccinea (Lem.) A. C. Smith, has led to the isolation of two new compounds characterized as 3-hydroxy-12-hydroxyl coccinic acid (1) and 3-hydroxy-neokadsuranic acid A (2). Their structures were established by 1D and 2D NMR techniques and mass spectroscopy. Antiproliferative effects of the isolated compounds were evaluated against four human tumor cell lines (A549, HCT116, HL-60 and HepG2), and it was found that compound 1 exhibited antiproliferative effects with IC(50) values ranging from 3.01 to 18.08 μg/mL.
|Alternate Journal:||Arch. Pharm. Res.|