Hodgsonia, Kadsura and Paris in Thailand

Conserved plants of Plant Genetic Conservation Project (RSPG)

A coumarin lignanoid from the stems of Kadsura heteroclita.

Publication Type:Journal Article
Year of Publication:2015
Authors:W. Su, Zhao, J., Yang, M., Yan, H. - W., Pang, T., Chen, S. - H., Huang, H. - Y., Zhang, S. - H., Ma, X. - C., Guo, D. - A., Khan, I. A., Wang, W.
Journal:Bioorg Med Chem Lett
Date Published:2015 Apr 1

Coumarinlignan (1), possessing a unique coumarin-containing lignan skeleton, was isolated from the stems of Kadsura heteroclita. Its structure and absolute configuration were determined by spectroscopic techniques, especially 2D NMR and X-ray crystallographic data analyses. The proposed biosynthetic pathway is discussed. This new compound showed good anti-HBV activity against HBeAg and HBsAg, and moderate anti-fibrotic and neuroprotective activities.

Alternate Journal:Bioorg. Med. Chem. Lett.
Scratchpads developed and conceived by (alphabetical): Ed Baker, Katherine Bouton Alice Heaton Dimitris Koureas, Laurence Livermore, Dave Roberts, Simon Rycroft, Ben Scott, Vince Smith